[Characteristics of hormonal homeostasis in adolescents with mental disorders]

Adolescents with mental disorder (residual organic conditions, psychopathy, schizophrenia, oligophrenia) were examined for hypophyseal thyroid and hypophyseal gonadal hormones in blood serum. The basic group included 98 subjects, the control one 25 mentally healthy subjects. Blood serum hormones were detected by RIA with the aid of kits of reagents manufactured in the USSR, France and Germany. The data obtained point to the presence of the latent hypothyroid condition in patients with psychopathy and schizophrenia, and in part of patients with associated residual organic brain injuries and manifest mental disorders. Comparative assessment of the content of tropic hormones of the pituitary and sex hormones in blood serum with regard to the puberty type has demonstrated that during the pubertal crisis, the study clinico-nosological groups manifested the predominance of disordered types of puberty: dysharmonious (34%), retarded (31%), and accelerated (6%). The hormonal characteristics and clinico-biochemical correlations confirm the role of hormonal disorders in the formation of psychopathological disturbances in adolescents experiencing the pubertal crisis.