Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Down syndrome and complete tracheal rings.

Miguel Neil C Bravo1, Ajay Kaul, Michael J Rutter

  • 1Division of Pediatric Otolaryngology Head and Neck Surgery, Gastroenterology, Hepatology & Nutrition, Cincinnati Children's Hospital Medical Center, OH 45229, USA.

The Journal of Pediatrics
|April 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms, prevention, and management of aminoglycoside-induced hearing loss in neonates and children: a translational review.

Frontiers in pharmacology·2026
Same author

Tracheomalacia and Tracheoesophageal Fistula.

Otolaryngologic clinics of North America·2026
Same author

American Gastroenterological Association-North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pediatric Functional Constipation Clinical Care Pathway.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Gastrointestinal Manifestations in Rubinstein-Taybi Syndrome.

American journal of medical genetics. Part A·2026
Same author

Dolichocolon in pediatric patients with constipation-The chicken or the egg?

Journal of pediatric gastroenterology and nutrition·2025
Same author

Safety and Efficacy of Pneumatic Balloon Dilation for Pediatric Achalasia-A Single-Center Experience.

The American journal of gastroenterology·2025
Same journal

Respiratory Syncytial Virus Immunization Disparities in Mothers and Infants at the Birth Hospitalization: A Cross-Sectional Study.

The Journal of pediatrics·2026
Same journal

Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Controlled Trial.

The Journal of pediatrics·2026
Same journal

Does Mild Head Injury in Childhood Affect Later School Performance? A Sibling Comparison Cohort Study.

The Journal of pediatrics·2026
Same journal

Risk Factors for Mortality and Age at Discharge in Preterm Infants with Congenital Heart Disease.

The Journal of pediatrics·2026
Same journal

To Cool or Not to Cool in Low- and Middle-Income Countries:? A Call for Resources, Training and Shared Knowledge.

The Journal of pediatrics·2026
Same journal

Responsible Research Practices in Pediatrics: How Reporting Guidelines Can Be Used to Improve Trial Design and Conduct.

The Journal of pediatrics·2026
See all related articles

Complete tracheal rings, a cause of tracheal stenosis, are now associated with Down syndrome. This study identified 7 children with both conditions, highlighting the need for increased awareness in diagnosing this airway anomaly in Down syndrome patients.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Genetics
  • Congenital Airway Anomalies

Background:

  • Tracheal stenosis is a rare but serious condition affecting the airway.
  • Complete tracheal rings are a congenital anomaly where the tracheal cartilage forms a complete circle.
  • This condition has not been previously linked to Down syndrome.

Observation:

  • Seven pediatric patients with Down syndrome were identified to also have complete tracheal rings.
  • The study observed variability in the clinical presentation of these patients.
  • Airway anatomy in these cases also showed significant variation.

Findings:

  • A novel association between Down syndrome and complete tracheal rings causing tracheal stenosis has been established.
  • The clinical manifestations and anatomical details of this combined condition are diverse.

Related Experiment Videos

  • Complete tracheal rings represent an important differential diagnosis in infants with Down syndrome presenting with respiratory issues.

    • Implications:

    • Clinicians should maintain a high index of suspicion for complete tracheal rings in children with Down syndrome, especially those with respiratory symptoms.
    • Early diagnosis and appropriate management are crucial for improving outcomes in this patient population.
    • This finding expands the spectrum of congenital anomalies associated with Down syndrome and necessitates tailored diagnostic and therapeutic approaches.