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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
A novel form of non-X-linked hyperigm associated with growth and pubertal disturbances and with lymphoma development
Viviana Moschese1, Jiri Lintzman, Francesco Callea
1Department of Pediatrics, University of Rome Tor Vergata, Italy. moschese@med.uniroma2.it
Abstract:
HyperIgM syndrome is a heterogenous immunodeficiency characterized by impaired class-switch recombination due to different molecular abnormalities. We report on two female patients affected by a novel syndrome associating HIGM, growth and pubertal disturbances, and severe lymphoid hyperplasia with eventual development into lymphomas, suggesting a DNA repair defect.
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