Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programming CD8+ T cells for effective immunotherapy.

Christian S Hinrichs1, Luca Gattinoni, Nicholas P Restifo

  • 1National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, MD 20892, USA.

Current Opinion in Immunology
|April 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptional and functional profiling reveals unique activation of Adapter CAR T cells in acute myeloid leukemia.

Journal of translational medicine·2026
Same author

Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse.

Cell·2026
Same author

Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity.

Cancer research·2026
Same author

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.

Nature immunology·2026
Same author

Impact of vector copy number on critical quality attributes of retrovirally engineered T cells.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

The science of tumor-infiltrating lymphocytes (TIL): perspectives from the SITC Surgery Committee.

Journal for immunotherapy of cancer·2025
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

CD8+ T cell differentiation is key for fighting tumors and infections. Epigenetic mechanisms control how these cells develop, offering new immunotherapy targets.

Area of Science:

  • Immunology
  • Cell Biology
  • Epigenetics

Background:

  • CD8+ T cell differentiation is critical for effective anti-tumor and anti-infection immunity.
  • T-cell receptor, co-stimulatory, and cytokine receptor signaling orchestrate this differentiation process.
  • Gene expression patterns are programmed by these signals, leading to progressive differentiation and lineage commitment.

Purpose of the Study:

  • To explore the epigenetic mechanisms governing CD8+ T cell differentiation.
  • To understand how sustained and heritable gene expression patterns are established.
  • To identify potential targets for novel immunotherapy strategies.

Main Methods:

  • The study focuses on elucidating the epigenetic mechanisms involved in T cell programming.

Related Experiment Videos

  • Specific signaling pathways and their impact on gene expression are investigated.
  • The research aims to uncover the molecular basis of lineage commitment in CD8+ T cells.

    • Main Results:

    • Epigenetic mechanisms are beginning to be understood as key regulators of CD8+ T cell differentiation.
    • These mechanisms ensure sustained and heritable gene expression patterns.
    • The findings highlight the importance of understanding T cell programming for immunotherapy.

    Conclusions:

    • Understanding CD8+ T cell differentiation is vital for developing effective immunotherapies.
    • Epigenetic control plays a significant role in T cell lineage commitment.
    • Further research into these mechanisms can advance cancer and infectious disease treatments.