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Updated: Aug 9, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
Published on: December 21, 2011
Reactive oxygen species signaling in vascular smooth muscle cells
Roza E Clempus1, Kathy K Griendling
1Department of Medicine, Division of Cardiology, Emory University, 319 WMB, 1639 Pierce Dr. Atlanta, GA 30322, USA.
Abstract:
Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.
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