3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors
Duncan Shaw1, Jonathan Best, Kevin Dinnell
1Department of Medicinal Chemistry, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. Duncan_shaw@merck.com
Bioorganic & Medicinal Chemistry Letters
|April 18, 2006
Abstract:
The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent gamma-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain A beta in transgenic mouse models and thus have potential as possible treatments for Alzheimer's disease.
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