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Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity.

Binu Tharakan1, Muralikrishnan Dhanasekaran, Holly M Brown-Borg

  • 1Plummer Movement Disorders Center, Department of Neurology, Scott & White Clinic, Temple, TX 76508, USA.

Phytotherapy Research : PTR
|April 18, 2006
PubMed
Summary

Trichopus zeylanicus whole plant powder demonstrated significant anti-fatigue effects in young and aged rats and mice. This study provides scientific evidence for traditional Kani tribal medicine practices.

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Area of Science:

  • Pharmacology
  • Ethnobotany
  • Animal Models

Background:

  • Chronic fatigue lacks effective pharmacological treatments.
  • Traditional medicine often holds potential therapeutic compounds.
  • Trichopus zeylanicus is used by the Kani tribe for fatigue.

Purpose of the Study:

  • To investigate the anti-fatigue efficacy of Trichopus zeylanicus whole plant powder.
  • To evaluate its effects in young and aged rodent models.
  • To scientifically validate traditional Kani tribal practices.

Main Methods:

  • Administration of Trichopus zeylanicus powder (250 and 500 mg/kg) to Sprague Dawley rats and Ames dwarf mice.
  • Assessment of fatigue using the forced swim test.
  • Exclusion of amphetamine-mimetic activity through specific tests.

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Main Results:

  • Trichopus zeylanicus significantly extended swim time in young Sprague Dawley rats (p < 0.005).
  • Oral administration increased mobility and swim time in aged normal and mutant mice (p < 0.05 to p < 0.01).
  • No amphetamine-mimetic activity was detected.

Conclusions:

  • Trichopus zeylanicus whole plant powder exhibits significant anti-fatigue properties.
  • The findings support the traditional use of this herb by the Kani tribe.
  • This research offers a potential natural therapeutic agent for fatigue.