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Giant perianal angiomyofibroblastoma--a case report.
Zdravko Perko1, Merica Glavina Durdov, Nikica Druzijanić
1University Department of Surgery, University Hospital Split, Split, Croatia. zperko@kbsplit.hr
Collegium Antropologicum
|April 19, 2006
Summary
A rare perianal angiomyofibroblastoma was completely excised in a 45-year-old female. This benign tumor showed no recurrence after 18 months, highlighting successful surgical management.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Perianal tumors require accurate diagnosis to differentiate benign from malignant conditions.
- Angiomyofibroblastoma is a rare mesenchymal tumor with a predilection for the vulvovaginal and perianal regions.
- Distinguishing angiomyofibroblastoma from aggressive locally invasive tumors like angiomyxoma is crucial for patient management.
Observation:
- A 45-year-old female presented with a slow-growing perianal tumor.
- Intraoperative findings revealed a well-circumscribed, encapsulated, and firm tumor measuring 12x6x4 cm.
- The tumor was completely excised using a Harmonic Scalpel.
Findings:
- Histological examination showed oval to spindle cells within a myxoid matrix, featuring numerous thin-walled blood vessels.
- Immunohistochemistry confirmed the expression of smooth-muscle actin, desmin, estrogen receptors, and progesterone receptors in tumor cells.
- The diagnosis of angiomyofibroblastoma was established based on these findings.
Implications:
- Complete surgical excision is an effective treatment for perianal angiomyofibroblastoma.
- Accurate histopathological and immunohistochemical analysis is essential for correct diagnosis and to rule out aggressive mimics.
- The favorable prognosis observed in this case suggests a benign clinical course for localized angiomyofibroblastoma.