Methylene blue for diagnosis of displaced atrial lines

Methylene blue (aniline violet, tetra-methylthionine chloride) has several important uses in clinical medicine, including diagnosis of displaced central lines. After cardiac surgery, three infants with suspected displacement of direct atrial lines were given methylene blue. After injection of the dye into the atrial lines, bluish discolouration was identified in their chest drainage. Use of methylene blue in small amounts appears to be a safe and effective way of diagnosing extravasation of fluid from displaced central lines.