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Amyloid beta protein substituent peptides do not interact with the substance P receptor expressed in cultured cells
M Mitsuhashi1, T Akitaya, C W Turk
1Division of Medical Sciences, Hitachi Chemical Research Center, Inc., Irvine, CA 92715.
Brain Research. Molecular Brain Research
|September 1, 1991
Abstract:
The amyloid beta protein (ABP) has been shown to interact with the substance P (SP) receptor in a cell culture model that may mimic the pathogenesis of Alzheimer's disease. In the present study, however, 4 fragments of ABP (beta 1-42, beta 1-16, beta 17-28, and beta 25-35) failed to interact with SP-induced Ca2+ mobilization in SP receptor-expressing cultured cells. Therefore, the action of these ABP-related peptides in our cultured cells is unrelated to the SP receptor.