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Updated: Aug 9, 2026
08:43
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
New treatments for superficial bladder cancer
Jay B Shah1, Gina M Badalato, James M McKiernan
1Department of Urology, Columbia University Medical Center, Herbert Irving Pavilion, 11th Floor, 161 Fort Washington Avenue, New York, NY 10032, USA. jmm23@columbia.edu
Current Oncology Reports
|April 19, 2006
Summary
New bladder cancer treatments are emerging, focusing on multimodality approaches and intravesical chemotherapy for superficial disease. Novel therapies like DNA vaccines offer hope for preventing recurrence and progression.
Area of Science:
- Urology
- Oncology
- Cancer Therapeutics
Background:
- Bladder cancer treatment presents ongoing challenges for clinicians.
- Recent advancements in the past five years have significantly altered therapeutic strategies for superficial bladder cancer.
- A shift towards multimodality treatment approaches is evident for all stages of bladder cancer.
Purpose of the Study:
- To review recent preclinical and clinical developments in bladder cancer therapeutics over the past year.
- To highlight emerging trends and novel treatment modalities for bladder cancer management.
Main Methods:
- Review of preclinical and clinical developments in bladder cancer therapeutics.
- Analysis of current treatment standards and emerging novel modalities.
Main Results:
- Intravesical instillation of chemotherapeutic agents post-transurethral resection is becoming standard for superficial bladder cancer.
- Novel therapeutic options under investigation include DNA vaccines, magnetically targeted carriers, bioadhesive microspheres, and antisense oligodeoxynucleotides.
Conclusions:
- The goals of complete tumor removal, prevention of recurrence, and inhibition of progression to invasive disease for superficial bladder cancer are increasingly achievable.
- Emerging therapeutic modalities suggest a promising future for improved bladder cancer outcomes.
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