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Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Helicobacter heilmanii gastritis in polymyositis
Isabelle Marie1, Fabien Hervé, Jean-Marc Kerleau
1Department of Internal Medicine, Centre Hospitalier Universitaire de Rouen-Boisguillaume, 76031 Rouen Cedex, France.
European Journal of Internal Medicine
|April 19, 2006
Summary
This study details a polymyositis patient with severe gastritis due to Helicobacter heilmanii. Eradication of H. heilmanii resolved symptoms, suggesting a potential link between polymyositis/dermatomyositis and gastric cancer risk.
Area of Science:
- Gastroenterology
- Rheumatology
- Infectious Diseases
Background:
- Polymyositis (PM) is an idiopathic inflammatory myopathy.
- Helicobacter heilmanii is a known cause of gastritis.
- Associations exist between PM/dermatomyositis (PM/DM) and gastric malignancies, and between H. heilmanii and gastric conditions.
Purpose of the Study:
- To report a case of severe gastritis in a PM patient caused by H. heilmanii.
- To investigate the potential increased risk of gastric malignancy in PM/DM patients with H. heilmanii infection.
Main Methods:
- Case report of a patient with polymyositis and H. heilmanii-associated gastritis.
- Treatment with triple therapy: omeprazole, metronidazole, and amoxicillin for H. heilmanii eradication.
Main Results:
- Successful eradication of H. heilmanii.
- Complete resolution of severe gastritis and digestive symptoms post-treatment.
- The patient's polymyositis remained stable.
Conclusions:
- H. heilmanii eradication can resolve gastritis in polymyositis patients.
- PM/DM patients infected with H. heilmanii may face an elevated risk for gastric malignancy.
- Further research is needed to confirm the link between Helicobacter species and gastric cancer in PM/DM patients.
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