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Related Experiment Videos

[Dietary fiber. Effect on colon carcinogenesis].

D W Bleyl1

  • 1Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Bundesrepublik, Deutschland.

Die Nahrung
|January 1, 1991
PubMed
Summary

Bile acids promote colon cancer by altering pH and metabolism. Specific plant-based foods, like bran, may delay cancer promotion, but dietary fiber alone does not offer protection.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Nutritional Science

Background:

  • Colon carcinogenesis is a multi-step process involving initiation and promotion.
  • Xenobiotics in human nutrition are typically present at concentrations too low to initiate cancer.
  • Bile acids are strongly implicated as promoters of colon carcinogenesis.

Purpose of the Study:

  • To investigate the role of bile acids in colon carcinogenesis.
  • To explore the mechanisms by which bile acids promote colon cancer.
  • To evaluate the protective effects of dietary fiber and specific plant products against colon cancer.

Main Methods:

  • Analysis of factors influencing bile acid promotion, including pH and metabolism.
  • Investigation of the impact of dietary lipid content on bile acid-related processes.
  • Assessment of the effects of dietary fiber and plant products (bran, lupin) on colon tumor development.

Main Results:

  • Factors influencing bile acid promotion likely involve decreased pH and altered bile acid metabolism (e.g., 7-alpha-dehydroxylase).
  • Dietary lipid content indirectly affects these processes via cholegenesis.
  • Dietary fiber did not show a protective effect; only specific plant products like bran and lupin demonstrated a delay in the promotion phase of colon carcinogenesis.

Conclusions:

  • Bile acids play a significant promoting role in colon carcinogenesis.
  • Dietary interventions targeting bile acid promotion, particularly through specific plant-derived products, may be beneficial.
  • The protective effects attributed to dietary fiber may be due to delayed promotion rather than direct prevention.

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