Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 12, 2026

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)
07:44

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)

Published on: September 27, 2010

Regional cerebral perfusion abnormalities in developmental language disorder. Statistical parametric mapping

Jun Won Hwang1, Jeong-Bum Lee, Boong-Nyun Kim

  • 1Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital, Chongnogu, Seoul, Korea.

European Archives of Psychiatry and Clinical Neuroscience
|April 19, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

Cancer research·2026
Same author

Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

Cancer research·2026
Same author

Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

Cancer research·2026
Same author

Editor's Note: Akt/mTOR Counteract the Antitumor Activities of Cixutumumab, an Anti-Insulin-like Growth Factor I Receptor Monoclonal Antibody.

Molecular cancer therapeutics·2026
Same author

Temporal proteomic characterization of SARS-CoV-2 infected mouse lungs.

Molecular & cellular proteomics : MCP·2026
Same author

Antisense oligonucleotides targeting Ninjurin1 ameliorate the pathology of lead- and cadmium-induced chronic obstructive pulmonary disease in mice.

Respiratory research·2026

Children with developmental language disorder (DLD) show reduced cerebral blood flow in key brain areas like the basal ganglia and inferior parietal lobe during rest. This suggests functional brain differences contribute to DLD

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Medical Imaging

Background:

  • Developmental Language Disorder (DLD) affects language acquisition in children.
  • Understanding the neurobiological underpinnings of DLD is crucial for early intervention.
  • Resting-state brain function may reveal subtle differences in children with DLD.

Purpose of the Study:

  • To investigate cerebral blood flow differences in children with DLD during a resting state.
  • To compare brain function between children with DLD and typically developing controls using voxel-based analysis.

Main Methods:

  • 21 children with DLD (DSM-IV criteria) and 17 controls underwent technetium-99m-HMPAO Brain SPECT.
  • SPM analyses were used for voxel-by-voxel comparison of SPECT images.

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Related Experiment Videos

Last Updated: Jul 12, 2026

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)
07:44

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)

Published on: September 27, 2010

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

  • ANCOVA was employed, covarying for age.

    • Main Results:

    • Children with DLD exhibited reduced cerebral blood flow in the right putamen, right inferior parietal cortex, and left globus pallidus.
    • No areas of increased cerebral blood flow were detected in the DLD group compared to controls.

    Conclusions:

    • Functional defects in the basal ganglia and inferior parietal lobe are present in the resting brains of children with DLD.
    • These findings support the role of basal ganglia functional deficits in the etiology of DLD.
    • Results highlight potential targets for future research and therapeutic strategies.