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[Biodegradable polymers for colon-specific drug delivery]
Witold Musiał1, Aleksander Kubis
1Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku we Wrocławiu. witold@bf.uni.wroc.pl
Polimery W Medycynie
|April 20, 2006
Summary
This review explores biodegradable polymers for targeted colon drug delivery, highlighting formulation, microflora, and cross-linking techniques. Future research aims to enhance delivery through synthetic polymers and absorption enhancers.
Area of Science:
- Pharmacology and Pharmaceutics
- Biomaterials Science
Context:
- Colon-specific drug delivery is crucial for treating colonic diseases.
- Biodegradable polymers offer promising platforms for targeted colonic drug release.
- Understanding colonic microflora and enzymatic activity is key for effective targeting.
Purpose:
- To review the use of biodegradable polymers for colon-specific drug delivery.
- To discuss formulation strategies, microflora influence, and cross-linking techniques.
- To outline the advantages and disadvantages of colon-specific drug delivery systems.
Summary:
- Focuses on biodegradable polymers like guar gum, chitosan, and pectin for colon drug delivery.
- Details colon-specific targeting principles, formulation, and the role of microflora.
- Examines cross-linking techniques and polymer mixtures for enhanced colonic drug targeting.
Impact:
- Highlights advancements in colon-specific drug delivery over the past three decades.
- Identifies areas for future research, including microflora interactions and absorption enhancers.
- Suggests the potential of synthetic polymers for improved colonic drug delivery.
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