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Published on: December 31, 2014
Myc/Max/Mad in invertebrates: the evolution of the Max network
1Universität Zürich, Zoologisches Institut, Winterthurerstrasse 190, 8057 Zürich, Switzerland. gallant@zool.unizh.ch
Abstract:
The Myc proto-oncogenes, their binding partner Max and their antagonists from the Mad family of transcriptional repressors have been extensively analysed in vertebrates. However, members of this network are found in all animals examined so far. Several recent studies have addressed the physiological function of these proteins in invertebrate model organisms, in particular Drosophila melanogaster. This review describes the structure of invertebrate Myc/Max/Mad genes and it discusses their regulation and physiological functions, with special emphasis on their essential role in the control of cellular growth and proliferation.
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