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Hygromycin B therapy of a murine coronaviral hepatitis
1Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
Antimicrobial Agents and Chemotherapy
|October 1, 1991
Abstract:
Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.