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Updated: Aug 9, 2026

Micropatterning and Assembly of 3D Microvessels
Published on: September 9, 2016
HGF-induced capillary morphogenesis of endothelial cells is regulated by Src
Shigeru Kanda1, Hiroshi Kanetake, Yasuyoshi Miyata
1Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki, Japan. skanda-jua@umin.net
Abstract:
The signal transduction pathway involved in hepatocyte growth factor (HGF)-induced capillary morphogenesis of endothelial cells was investigated. HGF-induced capillary morphogenesis of the murine spleen endothelial cell line MSS31 was inhibited by a Src family kinase inhibitor, PP2. Stable expression of kinase-inactive Src in MSS31 cells inhibited HGF-induced activation of Src as well as capillary morphogenesis. The HGF-induced capillary morphogenesis of human umbilical vein endothelial cells was also inhibited by PP2 and was reduced by the downregulation of Src by small interfering RNA. These results suggest that HGF induces capillary morphogenesis of endothelial cells through Src.
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