Related Experiment Video
Updated: Aug 9, 2026
08:13
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Segmental left ventricular wall motion abnormalities are associated with lacunar ischemic stroke
Dirk Deleu1, Saadat Kamran, Ayman A Hamad
1Department of Neurology, Hamad Medical Corporation, P.O. Box 3050, Doha, State of Qatar. doc_deleu@hotmail.com
Clinical Neurology and Neurosurgery
|April 20, 2006
Summary
Segmental left ventricular wall motion abnormalities (SLVWMA) are associated with a higher incidence of lacunar ischemic strokes, particularly in patients with multiple cardiovascular risk factors. The exact mechanisms linking SLVWMA to lacunar strokes remain unclear.
Area of Science:
- Cardiology
- Neurology
- Medical Imaging
Background:
- Ischemic stroke is a leading cause of disability and death.
- Segmental left ventricular wall motion abnormalities (SLVWMA) are a potential indicator of cardiac dysfunction.
- The relationship between SLVWMA and the occurrence of ischemic stroke, specifically lacunar strokes, requires further elucidation.
Purpose of the Study:
- To investigate the potential role of SLVWMA as a cause of ischemic stroke.
- To compare cardiovascular risk factors and echocardiographic parameters in ischemic stroke patients with and without SLVWMA.
- To analyze the association between SLVWMA and lacunar stroke subtypes.
Main Methods:
- Retrospective analysis of 259 ischemic stroke patients and 79 cardiac patients.
- Comparison of demographic data, cardiovascular risk factors, and echocardiographic parameters.
- Stratification of stroke patients based on the presence or absence of SLVWMA.
Main Results:
- Ischemic stroke patients with SLVWMA had a higher number of cardiovascular risk factors (3.7) compared to those without SLVWMA (2.7).
- A significantly higher proportion of lacunar strokes (76%) was observed in patients with SLVWMA compared to those without (68%).
- Cardiac patients without a history of stroke but with SLVWMA exhibited a lower ejection fraction (37%) than stroke patients.
Conclusions:
- SLVWMA may be associated with a higher frequency of lacunar strokes in patients with multiple cardiovascular risk factors.
- Lacunar strokes might serve as a marker for small-vessel disease or contribute to stroke development via cardiac microembolism.
- The precise mechanisms underlying the association between SLVWMA and lacunar ischemic stroke warrant further investigation.
Related Concept Videos
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...