Outbreak of epidemic methicillin-resistant Staphylococcus aureus in a regional burns unit: management and

Abid Rashid1, Livingstone K Solomon, Harry G Lewis

  • 1Northern Ireland Plastic and Maxillofacial Service, Ulster Hospital, Dundonald, Belfast, Northern Ireland BT16 1RH, UK. Abidrashid@aol.com

Insights

An epidemic of methicillin-resistant Staphylococcus aureus (MRSA) in a regional burns unit was successfully controlled. This outbreak highlights the significant impact on patient care, staff, and management protocols for burn services.

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Burn Care Management

Background:

  • Colonization with methicillin-resistant Staphylococcus aureus (MRSA) is common in burn patients, but outbreaks requiring unit closure are rare.
  • An epidemic strain, EMRSA-15, caused a significant MRSA outbreak in a regional adult burns unit.

Purpose of the Study:

  • To document the experience and management of an EMRSA-15 outbreak in a regional adult burns unit.
  • To analyze the implications of the outbreak on patient care, staff, and service provision.

Main Methods:

  • Investigated 176 admitted patients (52 burns, 48 plastic surgery) and 46 staff members for MRSA.
  • Implemented unit closure, staff treatment (nasal mupirocin, triclosan body wash), and unit decontamination.
  • Monitored MRSA isolation rates in patients and staff.

Main Results:

  • MRSA was isolated in 18 patients (12 EMRSA-15) and nine staff members (5 EMRSA-15).
  • The burns unit was closed to new admissions to contain the outbreak.
  • Staff treatment and unit decontamination led to successful outbreak termination, with staff returning to work after one week.

Conclusions:

  • The EMRSA-15 outbreak was successfully controlled through a multi-faceted approach including unit closure and targeted treatment.
  • The study underscores the critical impact of such outbreaks on regional burn services, affecting patient management, staff resources, and the need for robust infection control guidelines.

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...