[The dependence of the impulse reactions in surviving cortex slices on the stimulation parameters]

The dependence of evoked neuronal discharges on stimulus electrode position, on power, frequency and duration of stimulation was investigated in guinea-pig neocortical slices. At suprathreshold stimulus intensity and under low frequency (about 0.1/s) and limited duration of stimulus series (10-30) the discharge pattern was usually well preserved. A, more intensive, higher-frequency or too long stimulation often led to transient habituation of responses. When the distances from neuron to the stimulus sites were equal the radial propagation of excitation seemed to be easier than tangential one.