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Updated: Aug 9, 2026

Terminal H-reflex Measurements in Mice
Published on: June 16, 2022
Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of
Dobrivoje S Stokic1, Stuart A Yablon, Antonio Hayes
1Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA. dstokic@mmrcrehab.org
Objective:
To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia.
Methods:
Soleus H-reflexes were serially recorded in 34 subjects (19 men, mean age 32 years, mean follow-up 1.7 years) during simple continuous mode of CITB delivery. Different fitting methods were explored to determine which function best described changes in H/M ratio with increasing CITB dose. We then calculated effective CITB doses yielding H/M ratios equal to 75, 50, and 25% (ED75, ED50, ED25) of the baseline recorded before the implant in 22 subjects.
Results:
We found a significant dose-response relationship between the soleus H/M ratio and CITB dose. A two-decay exponential function was the best fit on each side for pooled data, but a general linear model when controlling for subject. The mean ED75, ED50, ED25 were 30, 70, and 110 mcg/day. Logistical regression predicted with high probability that the H/M ratio should be less than 30% at CITB doses above 150 mcg/day.
Conclusions:
H/M ratio is strongly dependent on CITB dose. It sharply decreases up to 150 mcg/day of CITB followed by a plateau.
Significance:
Establishing the relationship between the H/M ratio and CITB dose may be useful for dose titration and early identification of an ITB system malfunction.
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