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Penetration of rufloxacin into human prostatic tissue and fluid
1Medical Research Bureau International, Druten, The Netherlands.
Abstract:
The penetration of rufloxacin into prostatic tissue and prostatic fluid was investigated in 16 patients undergoing elective transurethral prostate resection. Rufloxacin 400 mg was given orally approximately 16 h before surgery with a further dose of 200 mg approximately 5 h before surgery. Sampling was inadequate in three patients. One patient reported transient flushing and headache after the first dose of rufloxacin and was hence withdrawn from the study. In the remaining 12 evaluable patients, the mean ratios of rufloxacin concentrations (determined by HPLC) in prostatic tissue and fluid to the plasma concentration were 1.9 and 1.5, respectively. There were no significant differences between the tissue penetration ratios in different parts of the prostate. The levels of rufloxacin found in prostate tissue and fluid, in this study, exceeded the MICs for most micro-organisms causing chronic bacterial prostatitis.
Insights
Rufloxacin effectively penetrates prostate tissue and fluid, achieving concentrations above minimum inhibitory levels for common prostatitis pathogens. This suggests potential efficacy in treating chronic bacterial prostatitis.
Area of Science:
- Pharmacology
- Urology
- Infectious Diseases
Background:
- Chronic bacterial prostatitis (CBP) is often treated with antibiotics.
- Effective antibiotic penetration into prostatic tissue and fluid is crucial for treatment success.
Purpose of the Study:
- To investigate the penetration of rufloxacin into human prostatic tissue and prostatic fluid.
- To determine if rufloxacin concentrations in the prostate exceed the minimum inhibitory concentrations (MICs) for common CBP pathogens.
Main Methods:
- 16 patients undergoing transurethral prostate resection received oral rufloxacin (400 mg ~16h pre-op, 200 mg ~5h pre-op).
- Prostatic tissue, prostatic fluid, and plasma samples were collected and analyzed for rufloxacin concentration using High-Performance Liquid Chromatography (HPLC).
- Concentration ratios (prostate/plasma) were calculated for 12 evaluable patients.
Main Results:
- Mean rufloxacin concentration ratios in prostatic tissue and fluid to plasma were 1.9 and 1.5, respectively.
- No significant differences in tissue penetration were observed across different prostate regions.
- Achieved rufloxacin levels exceeded MICs for most bacteria implicated in CBP.
Conclusions:
- Rufloxacin demonstrates significant penetration into prostatic tissue and fluid.
- The drug concentrations achieved suggest potential therapeutic benefit for chronic bacterial prostatitis.
- Further clinical studies are warranted to confirm rufloxacin's efficacy in CBP treatment.