Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Piperacillin/tazobactam-induced paresthesiae.

Jonathan Lambourne1, Joanne Kitchen, Claudine Hughes

  • 1Department of Infectious Disease and Genitourinary Medicine, St James's Hospital, Dublin, Ireland. jonnylambourne@yahoo.com

The Annals of Pharmacotherapy
|April 20, 2006
PubMed
Summary

This case report details a delayed-type hypersensitivity (DTH) reaction to piperacillin/tazobactam, presenting with painful paresthesiae. This hypersensitivity reaction also included fever, neutropenia, and thrombocytopenia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying barriers to hepatitis C virus elimination in the era of direct-acting antivirals.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Blood culture pathways in UK hospitals: an exploratory survey.

The Journal of hospital infection·2026
Same author

Correction: Standardization of 16S rRNA gene sequencing using nanopore long read sequencing technology for clinical diagnosis of culture negative infections.

Frontiers in cellular and infection microbiology·2026
Same author

Emerging terbinafine-resistant Trichophyton indotineae between 2018 and 2023: a multinational genomic epidemiology study.

The Lancet. Microbe·2026
Same author

Travel-associated carbapenem-resistant organisms at a time of increasing geopolitical instability: a UK perspective.

The Journal of hospital infection·2025
Same author

Rapid emergence of <i>Trichophyton indotineae</i> (<i>Trichophyton mentagrophytes</i> ITS genotype VIII) observed in the United Kingdom, up to August 2025.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2025

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Immunology

Background:

  • Piperacillin/tazobactam is a commonly used antibiotic combination.
  • Delayed-type hypersensitivity (DTH) reactions are immune responses that occur 24-72 hours after exposure to an antigen.
  • Paresthesiae, or abnormal sensations like tingling or prickling, can be a symptom of various medical conditions.

Observation:

  • A 27-year-old male patient developed symptoms suggestive of a DTH reaction after two weeks of piperacillin/tazobactam treatment for a pulmonary abscess.
  • The patient experienced fever, chills, neutropenia, and thrombocytopenia.
  • Notably, the patient also reported painful paresthesiae associated with the antibiotic infusion.

Findings:

  • The patient's symptoms and laboratory abnormalities resolved within 48 hours after switching to flucloxacillin.

Related Experiment Videos

  • The Naranjo probability scale indicated a probable relationship between the paresthesiae and piperacillin/tazobactam administration.
  • This is the first reported case of a DTH reaction to piperacillin/tazobactam with prominent paresthesiae.

    • Implications:

    • Paresthesiae should be considered a potential symptom of piperacillin/tazobactam-induced DTH reactions.
    • Clinicians should be aware of this atypical presentation when prescribing piperacillin/tazobactam.
    • Further research may be warranted to understand the mechanism linking DTH reactions to paresthesiae.