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O Adighibe1, K Micklem, L Campo

  • 1Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, 35 Convent Drive, Bethesda, MD 20892, USA.

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...