Comparative clinical study of preterm and full-term newborn neonatal seizures

To compare the characteristics of neonatal seizures between preterm and full-term infants in intensive care unit.

A prospective study was developed with 104 high-risk newborn, 30 preterm and 74 full-term infants, with clinical seizures. The dependent variable was gestational age.

Fisher's exact test, odds-ratio and Mann Whitney U test.

There were significant differences (p<0.05): i) Premature neonates develop neonatal seizures later, probably related to the etiologies of the seizures; ii) Etiologically, there is a predominance of peri-intraventricular hemorrhage in preterm and of asphyxia in full term neonates; iii) Clonic seizures are most frequent in preterm and subtle seizures in full term neonates.

Although the study had a clinical basis, it was possible to identify differences when the dependent variable was gestational age.