Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medication errors and patient complications with continuous renal replacement therapy.

Jeffrey F Barletta1, Gina-Marie Barletta, Patrick D Brophy

  • 1Department of Pharmacy, Spectrum Health, 100 Michigan St NE (MC001), Grand Rapids, MI 49503, USA. Jeffrey.Barletta@spectrum-health.org

Pediatric Nephrology (Berlin, Germany)
|April 20, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tranexamic acid in patients with traumatic brain injury: Is there benefit in patients with fibrinolytic shutdown?

The journal of trauma and acute care surgery·2026
Same author

A Comparison of Phenobarbital Dosing Strategies for the Treatment of Alcohol Withdrawal Syndrome.

The Annals of pharmacotherapy·2026
Same author

A survey of stress ulcer prophylaxis practice patterns for critically ill patients before and after participating in a randomised controlled trial.

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses·2026
Same author

Pharmacists in Interprofessional Critical Care: Optimizing Medication Management.

Critical care clinics·2026
Same author

Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients.

JAMA network open·2025
Same author

Safety and Efficacy of Tolvaptan for Acute Refractive Hyponatremia Associated with Traumatic Brain Injury.

Journal of clinical medicine·2025

Medication errors during continuous renal replacement therapy (CRRT) are frequent and severe, especially with manually compounded solutions. Using commercially available solutions significantly reduces these critical errors in pediatric intensive care units.

Area of Science:

  • Pediatric critical care medicine
  • Nephrology
  • Clinical pharmacy

Background:

  • Continuous renal replacement therapy (CRRT) is a vital renal support method in intensive care units.
  • Medication errors in ICUs are documented, but CRRT-specific errors remain undercharacterized.
  • The safety of CRRT practices, particularly concerning medication preparation, requires detailed investigation.

Purpose of the Study:

  • To identify and characterize medication errors associated with CRRT.
  • To compare the incidence and severity of medication errors between manually compounded and commercially available CRRT solutions.
  • To assess the impact of solution preparation methods on patient safety in CRRT.

Main Methods:

  • A survey was distributed via internet-based pediatric list serves for CRRT programs.

Related Experiment Videos

  • Data collected included CRRT practices, medication errors, and solution compounding methods (manual vs. commercial).
  • Medication errors were graded for severity, and comparisons were made between different preparation strategies.

    • Main Results:

    • Out of 31 responding programs, 18 reported medication errors related to CRRT.
    • The majority of errors (16/18) stemmed from solution compounding, with two related to heparin.
    • Half of the reported errors caused harm, including two fatal events, all occurring in programs using manual compounding.

    Conclusions:

    • Medication errors in CRRT are associated with significant morbidity and mortality.
    • Manual compounding of CRRT solutions presents a substantial risk for medication errors.
    • Transitioning to industry-based, commercially available CRRT solutions can mitigate medication errors and enhance patient safety.