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Isolated office hypertension: association with target organ damage and cardiovascular risk indices

Nuri Kamel1, Alptekin Gursoy, Osman Koseoglulari

  • 1Department of Endocrinology and Metabolic Diseases, School of Medicine, Ankara University, Turkey.

Journal of the National Medical Association
|April 21, 2006
PubMed

Insights

Isolated office hypertension (IOH) causes target organ damage, including increased carotid intima-media thickness and left ventricular mass index. This condition is not benign and requires attention for cardiovascular risk management.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Medicine

Background:

  • Isolated office hypertension (IOH) is debated regarding its clinical significance.
  • Some view IOH as benign, while others suspect cardiovascular abnormalities and increased risk.

Purpose of the Study:

  • To evaluate the impact of IOH on target organ damage.
  • To assess cardiovascular risk indices in patients with IOH.

Main Methods:

  • Compared 33 IOH patients, 17 sustained hypertension patients, and 17 controls.
  • Measured office BP, 24-hour ambulatory BP (ABMP), carotid intima-media thickness (CIMT), and left ventricular mass index (LVMI).
  • Assessed cardiothoracic index (CTI), QTc duration, microalbuminuria, and lipid profiles.

Main Results:

  • IOH patients showed increased CIMT compared to controls, but less than sustained hypertension patients.
  • LVMI was significantly higher in IOH subjects versus controls.
  • No significant differences were found in CTI, QTc, microalbuminuria, or lipid profiles among groups.

Conclusions:

  • IOH is associated with significant target organ damage.
  • IOH should not be considered a benign condition.
Abstract

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