Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular depth profiling with cluster ion beams.

Juan Cheng1, Andreas Wucher, Nicholas Winograd

  • 1Chemistry Department, Pennsylvania State University, 104 Chemistry Building, University Park, Pennsylvania 16802, USA.

The Journal of Physical Chemistry. B
|April 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amino Acid-Directed Synthesis of Chiral Manganese Chlorides with One-Dimensional Helical Structures.

Inorganic chemistry·2026
Same author

Safety Profile of COVID-19 Vaccines in HIV Patients Undergoing ART and Their Impact on Immune Recovery and HIV Reservoirs.

Infectious diseases & immunity·2026
Same author

Motor Cortex VIP Interneurons Participate in Dexmedetomidine-Associated Sleep Modulation.

Molecular neurobiology·2026
Same author

High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial <i>ex vivo</i> improvement by ML-7.

Frontiers in cardiovascular medicine·2026
Same author

Impact of continuous care based on multidisciplinary collaboration on the quality of life of patients with colorectal cancer undergoing chemotherapy.

Frontiers in medicine·2026
Same author

Drug-tolerant persister cells: the deadly survivors in hematological malignancies.

Frontiers in pharmacology·2026
Same journal

From Cation Solvation to Anion Coordination: Lewis-Acidic Boranes Enable Halide Salt Electrolytes.

The journal of physical chemistry. B·2026
Same journal

In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.

The journal of physical chemistry. B·2026
Same journal

Metastructure Analysis of Self-Assembled Nanocubes with Different Equatorial Methyl Groups Based on Molecular Dynamics Simulations.

The journal of physical chemistry. B·2026
Same journal

A Cocoordinated <sup>1</sup>H Internal Reference Quantifies Proton-Exchange Bias in Coordinated-Water Diffusion.

The journal of physical chemistry. B·2026
Same journal

Unveiling Electrolyte-Dependent Coordination Site Dynamics for Redox Mediator Design in Lithium-O<sub>2</sub> Batteries: Exchange vs Rearrangement.

The journal of physical chemistry. B·2026
Same journal

The Role of Functional Groups in Substituted Benzoic Acids Used as Dopants in Liquid Crystal Mixtures on the Nematic-Isotropic Transitions.

The journal of physical chemistry. B·2026
See all related articles

Energetic cluster ion beams of C60+ and gold (Au) were used to study molecular depth profiling of peptide-doped trehalose thin films. Optimal conditions for depth profiling involve high sputtering yield and minimal altered layer thickness.

Area of Science:

  • Materials Science
  • Surface Science
  • Analytical Chemistry

Background:

  • Peptide-doped trehalose thin films offer a reproducible system for studying molecular sputtering.
  • Understanding molecular sputtering is crucial for accurate depth profiling of complex materials.

Purpose of the Study:

  • To investigate the molecular sputtering process of peptide and trehalose in thin films using energetic cluster ion beams.
  • To develop and validate an analytical model for molecular depth profiling.

Main Methods:

  • Bombardment of thin films with C60+ and Aux+ (x=1,2,3) cluster ion beams.
  • Measurement of secondary ion mass spectra during ion beam erosion.
  • Analysis of molecular ion intensity as a function of ion dose.

Related Experiment Videos

Main Results:

  • An analytical model was developed to describe molecular ion intensity, incorporating sputtering yield, damage cross section, and altered layer thickness.
  • Favorable depth profiling conditions require high sputtering yield and low altered layer thickness.
  • C60+ bombardment yielded successful depth profiles with a low degree of chemical damage accumulation.

Conclusions:

  • The presented model provides guidance for optimizing molecular depth profiling experiments.
  • C60+ and Au cluster ions are effective projectiles for depth profiling of these thin films.
  • Experimental parameters like sputtering yield and altered layer thickness are key to successful molecular depth profiling.