Related Experiment Videos
[Salmonella infections in Kinshasa: the species involved and sensitivity to antibiotics]
1Département de pédiatrie, cliniques universitaires, Kinshasa, République du Zaïre.
Abstract:
292 Salmonella strains were isolated between 1986-1988 in the bacteriological unit of the Cliniques Universitaires de Kinshasa (Zaïre). One hundred of these strains were isolated from pediatric samples. The most frequent strains were S typhi, S enteritidis and S typhimurium. S typhi strains were sensitive to all antibiotics tested. The other salmonella serotypes had an increasing resistance to several antibiotics especially ampicillin, streptomycin, tetracyclin and kanamycin. A significant decline was observed with chloramphenicol and sulfamethoxazol-trimetoprim. Stool-isolated strains from children were found to be resistant to all antibiotics in common use in 5/6 cases. In systemic Salmonella infection, treatment with chloramphenicol or sulfamethoxazole-trimetoprim plus gentamycin is probably preferable to any other antibiotic recommended for Salmonella infection.
Insights
Salmonella strains in Kinshasa show increasing antibiotic resistance, particularly in children. Chloramphenicol or sulfamethoxazole-trimetoprim plus gentamycin is recommended for systemic infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Study conducted in Kinshasa, Zaire (1986-1988) analyzing 292 Salmonella strains.
- Focus on pediatric samples (100 strains) and common serotypes like S. typhi, S. enteritidis, and S. typhimurium.
- Investigated antibiotic susceptibility patterns of isolated Salmonella strains.
Purpose:
- To assess the antibiotic resistance profiles of Salmonella serotypes prevalent in Kinshasa.
- To identify effective treatment options for Salmonella infections, especially in pediatric cases.
- To track trends in antimicrobial resistance over the study period.
Summary:
- Salmonella typhi strains exhibited sensitivity to all tested antibiotics.
- Other serotypes demonstrated increasing resistance to ampicillin, streptomycin, tetracycline, and kanamycin.
- A notable decrease in resistance was observed for chloramphenicol and sulfamethoxazole-trimetoprim.
- Stool isolates from children showed high resistance (5/6 cases) to commonly used antibiotics.
- Salmonella strains from pediatric samples exhibited significant resistance patterns.
Impact:
- Highlights the emergence of multidrug-resistant Salmonella in a specific geographic region.
- Informs clinical practice regarding preferred antibiotic regimens for Salmonella infections, particularly in children.
- Underscores the need for ongoing surveillance of antimicrobial resistance in bacterial pathogens.