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Gabapentin-induced coma in a patient with renal failure.

Ayhan Dogukan1, Bilge Aygen, Muhammed S Berilgen

  • 1Divison of Nephrology, Firat University, Elazig, Turkey. aydogukan@hotmail.com

Hemodialysis International. International Symposium on Home Hemodialysis
|April 21, 2006
PubMed
Summary

A single gabapentin dose caused coma in a woman with normal kidney function. Hemodialysis improved her condition, highlighting the risk of gabapentin toxicity in patients with renal impairment.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Neurology

Background:

  • Gabapentin is a commonly prescribed anticonvulsant and analgesic.
  • Sciatalgia, or sciatic pain, is a common condition often treated with gabapentin.
  • Renal function plays a crucial role in drug metabolism and excretion.

Observation:

  • A 60-year-old woman presented with coma after receiving a single dose of gabapentin for right-sided sciatalgia.
  • The patient's neurological status significantly improved following hemodialysis treatment.

Findings:

  • This case suggests a potential link between gabapentin administration and acute neurological toxicity, even in patients without pre-existing renal failure.
  • Hemodialysis effectively removed gabapentin from the bloodstream, leading to clinical improvement.

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Implications:

  • Clinicians should consider gabapentin toxicity in patients presenting with altered mental status, particularly those with impaired renal function.
  • Careful dosing and monitoring of gabapentin are essential, especially in vulnerable patient populations.
  • This case underscores the importance of considering drug-induced toxicity in differential diagnoses for neurological changes.