Related Experiment Video
Updated: Aug 9, 2026
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
NANOGP8 is a retrogene expressed in cancers
Jingyu Zhang1, Xia Wang, Meixiang Li
1Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing.
NANOGP8, a Nanog pseudogene, is expressed in cancers and promotes cell proliferation. This suggests NANOGP8 may play a role in tumorigenesis and has potential regulatory functions.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Nanog is crucial for human embryonic stem cell pluripotency.
- NANOGP8, a Nanog pseudogene, was previously uncharacterized due to lack of expression data.
Purpose of the Study:
- To investigate the expression and function of the NANOGP8 pseudogene.
- To explore the potential role of NANOGP8 in cancer and cell proliferation.
Main Methods:
- Cloning of the complete coding sequence of NANOGP8.
- Detection of NANOGP8 expression in cancer cell lines and tissues via protein expression analysis.
- Assessing the effect of NANOGP8 expression on NIH3T3 cell proliferation.
Main Results:
- NANOGP8 expression was detected in various cancer cell lines and tissues.
- NANOGP8 shares high sequence homology with Nanog.
- NANOGP8 protein expression was confirmed.
- NANOGP8 expression promoted cell proliferation in NIH3T3 cells.
Conclusions:
- NANOGP8 is expressed in cancers and may contribute to tumorigenesis.
- This finding highlights potential regulatory roles for human pseudogenes.
- NANOGP8 has implications for stem cell and cancer research.
More Related Videos
08:57Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
09:33Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...