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[Serum resistin concentration and insulin resistance in obese children]

Ge-li Liu1, Xiao-hui Fu, Li-hong Jiang

  • 1Department of Pediatrics, General Hospital of Tianjin Medical University, Tianjin 300052, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics
|April 21, 2006
PubMed

Insights

Obese children have higher resistin levels, which correlate with obesity and fat distribution. This suggests resistin may play a role in developing insulin resistance and hyperinsulinemia in this population.

Area of Science:

  • Endocrinology
  • Pediatrics
  • Metabolic Syndrome

Background:

  • Obesity is a significant risk factor for insulin resistance and type 2 diabetes.
  • Adipocytes secrete factors like resistin that regulate energy balance.
  • Resistin's role in pediatric obesity and metabolic dysfunction requires further investigation.

Purpose of the Study:

  • To investigate the correlation between serum resistin levels and anthropometric/metabolic parameters in obese children.
  • To explore the association of resistin with hyperinsulinemia and insulin resistance in this cohort.

Main Methods:

  • Serum resistin concentrations were measured using ELISA in 34 obese children and 31 normal-weight controls.
  • Anthropometric data, fasting glucose, insulin, HOMA-R (insulin resistance), and HOMA-beta (beta-cell function) were assessed.
  • Correlation and multiple linear regression analyses were performed.

Main Results:

  • Obese children exhibited significantly higher serum resistin concentrations compared to normal subjects (P < 0.05).
  • Resistin positively correlated with BMI, body fat percentage, waist-hip ratio, fasting glucose, fasting insulin, and HOMA-R (P < 0.01).
  • Multiple regression analysis identified HOMA-R as the sole significant predictor of resistin levels (R² = 0.105, P < 0.01).

Conclusions:

  • Elevated serum resistin levels are observed in obese children.
  • Resistin concentrations are linked to the degree of obesity and fat distribution.
  • Resistin is implicated in the pathogenesis of hyperinsulinemia and insulin resistance in obese children.
Abstract

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