Related Experiment Video
Updated: Aug 9, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
[The application of adenosine stress myocardial perfusion tomographic imaging in detecting coronary artery disease]
Zhong-jie Fan1, Li-bo Chen, Fang Li
1Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. zhjfan@yahoo.com
Insights
Adenosine stress myocardial perfusion imaging effectively detects coronary artery disease (CAD) with 88% sensitivity. This non-invasive test aids in diagnosing CAD, showing good diagnostic performance.
Area of Science:
- Cardiology
- Nuclear Medicine
- Diagnostic Imaging
Background:
- Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
- Accurate non-invasive diagnostic methods are crucial for timely intervention.
Purpose of the Study:
- To evaluate the diagnostic accuracy of adenosine stress myocardial perfusion tomographic imaging for CAD.
- To determine the sensitivity and specificity of this imaging technique.
Main Methods:
- Adenosine infusion (140 µg/kg/min for 6 min) followed by 99mTc-MIBI injection.
- SPECT myocardial perfusion imaging acquired 1.5 hours post-infusion.
- Coronary angiography performed within one week for definitive diagnosis.
Main Results:
- Adenosine stress SPECT showed 88.0% sensitivity and 65.5% specificity for CAD diagnosis in 79 patients.
- Positive scans were observed in 44 of 50 CAD patients.
- No severe adverse effects were reported during the adenosine stress test.
Conclusions:
- Adenosine stress myocardial perfusion tomographic imaging is a valuable non-interventional tool for detecting CAD.
- The technique demonstrates good sensitivity for diagnosing coronary artery stenosis.
Objective:
To analyze the sensitivity and specificity of adenosine stress myocardial perfusion tomographic imaging for the diagnosis of coronary artery disease (CAD).
Methods:
Adenosine was infused intravenously at a rate of 140 microg.kg(-1).min(-1) for 6 minutes. 3 minutes after adenosine infusion, 925 MBq of (99m)Tc-MIBI were injected intravenously. SPECT myocardial imaging acquisition was obtained 1.5 hours after adenosine infusion. If the result was abnormal, rest myocardial perfusion imaging would be performed next day. Coronary angiography was performed in all patients within one week of myocardial imaging.
Results:
Total 79 cases [(62 +/- 10) years old, 35 men, 44 women] were included in this study. In the 50 cases of CAD patients confirmed by coronary angiography, 44 patients have positive adenosine (99m)Tc-MIBI myocardial perfusion SPECT. Nineteen out of 29 cases without CAD have negative adenosine myocardial perfusion tomographic imaging. The sensitivity and specificity of adenosine myocardial perfusion tomographic imaging for the diagnosis of CAD were 88.0% and 65.5%. The sensitivity of adenosine myocardial perfusion tomographic imaging for diagnosing coronary stenosis in left anterior descending, left circumflex and right coronary artery are 32/40, 21/27 and 31/32. There was no severe adverse side effect during adenosine stress test.
Conclusion:
Adenosine stress myocardial perfusion tomographic imaging is an useful non-interventional method for detecting coronary artery disease.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:28Imaging Studies for Cardiovascular System V: CT
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:21Imaging Studies for Cardiovascular System IV: CMRI