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[Experiences with monoclonal antibody orthoclone OKT3 following liver transplantation]
H Kraemer-Hansen1, D Henne-Bruns, S Schröder
1Chirurgische Universitätsklinik, Universität Hamburg.
Zeitschrift Fur Gastroenterologie
|September 1, 1991
Abstract:
In 7 patients 10 cycles (5 to 21 days, dosage: 30 to 430 mg, median 138 mg) of OKT3 therapy were performed after liver transplantation. In all patients reactivation of an EBV-infection with hepatitis was observed. Two patients treated with high dosages (430 mg respectively 195 mg) developed lymphoproliferative lesions. In one patient with persistent EBV-infection (dosage: 360 mg) a B-cell-lymphoma was diagnosed. This patient died 26 months after transplantation.