Related Experiment Video
Updated: Aug 9, 2026
08:21
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
Published on: June 15, 2020
Impact of bronchiectasis on right and left ventricular functions
Mehmet Gencer1, Erkan Ceylan, Remzi Yilmaz
1The Department of Chest Disease, Faculty of Medicine, Harran University, Sanliurfa, Turkey. drmehmetgencer@yahoo.com
Respiratory Medicine
|April 21, 2006
Summary
Patients with bronchiectasis show impaired right and left ventricular functions. Right ventricular dysfunction is linked to disease severity and oxygen levels, while left ventricular dysfunction correlates with right ventricular function.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Bronchiectasis can lead to increased workload on the heart due to systemic-pulmonary shunts and chronic hypoxemia.
- Assessing ventricular function is crucial for understanding the cardiac impact of bronchiectasis.
Purpose of the Study:
- To evaluate right ventricular (RV) and left ventricular (LV) function in bronchiectasis patients.
- To utilize the myocardial performance index (MPI) derived from tissue Doppler imaging as a sensitive parameter for assessing ventricular function.
Main Methods:
- A study involving 25 patients diagnosed with bronchiectasis.
- Comparison of RV and LV MPI values with 22 age- and gender-matched healthy control subjects.
- Calculation of MPI, a combined index of systolic and diastolic function, for both ventricles.
Main Results:
- Significant differences in RV and LV MPI were observed between bronchiectasis patients and controls.
- RV MPI correlated with the number of involved lung lobes, arterial oxygen pressure, and pulmonary flow characteristics (acceleration time/ejection time).
- LV MPI showed a correlation only with RV MPI, not with clinical parameters.
Conclusions:
- Ventricular dysfunction is present in patients with bronchiectasis.
- RV dysfunction is associated with disease extent and hypoxemia.
- LV dysfunction appears secondary to or associated with RV dysfunction in this patient group.
Related Concept Videos
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:20Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
01:26Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
01:26Heart Failure III: Clinical Manifestations
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...