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Updated: Aug 19, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Negative-regulatory role of calmodulin in the expression of interferon-beta gene
1Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo.
Abstract:
Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures producing biologically active IFN-beta in response to Sendai virus, results in a significant increase in IFN-beta production. This increase in IFN-beta production is observed 1 h after addition of TFP. The increase in IFN-beta production is correlated with increase in IFN-beta mRNA synthesis. Results suggest that calmodulin or calmodulin-dependent cellular process is involved in negative regulation of IFN-beta gene.
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