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Prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes

Tongwen Sun1, Lexin Wang, Yanzhou Zhang

  • 1Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, People's Republic of China.

Archives of Medical Research
|April 21, 2006
PubMed

Insights

B-type natriuretic peptide (BNP) levels predict cardiac death in Chinese acute coronary syndrome (ACS) patients. Higher BNP concentrations indicate increased risk, establishing BNP as a valuable prognostic marker.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Medicine

Background:

  • B-type natriuretic peptide (BNP) is released by ventricles due to wall tension in heart failure.
  • The predictive value of blood BNP for cardiac death in Chinese acute coronary syndrome (ACS) patients remains unclear.

Purpose of the Study:

  • To investigate the significance of blood BNP in predicting cardiac death among Chinese patients with ACS.

Main Methods:

  • Blood BNP levels were measured in 106 ACS patients within 1-3 days of symptom onset.
  • Patients were followed for 6 months to assess mortality and cardiovascular events.

Main Results:

  • Cardiac death occurred in 13 patients; 12 were hospitalized for ACS recurrence or heart failure.
  • The non-survival group had significantly higher mean blood BNP concentrations (median 1132 vs. 116 ng/L, p <0.001).
  • Multivariate analysis confirmed BNP as an independent predictor of cardiac death (OR=21.19, p <0.001).

Conclusions:

  • Blood BNP is a useful parameter for predicting cardiac death in Chinese ACS patients.
  • Elevated BNP levels are associated with increased risk of cardiac mortality in this population.
Abstract

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