Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A regression spline model for developmental toxicity data.

Daniel L Hunt1, Chin-Shang Li

  • 1Department of Biostatistics, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA. daniel.hunt@stjude.org

Toxicological Sciences : an Official Journal of the Society of Toxicology
|April 21, 2006
PubMed
Summary

A new B-spline model effectively characterizes nonlinear dose-response patterns in developmental toxicity data. This flexible regression approach improves upon traditional models for assessing risks of noncarcinogenic substances.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase 2 trial of exercise and low-dose ibuprofen for cancer-related cognitive impairment in patients receiving chemotherapy.

Cancer·2026
Same author

Penalized estimation of linear transformation models for interval-censored data with time-dependent covariates.

Statistical methods in medical research·2026
Same author

Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Walking dose associated with lower cancer-related fatigue among patients with breast cancer.

Journal of the National Cancer Institute·2025
Same author

Penalized estimation of general frailty Poisson models for recurrent count events.

Statistical methods in medical research·2025
Same author

Longitudinal assessment of cognitive function in patients with breast cancer and lymphoma receiving chemotherapy.

JNCI cancer spectrum·2025

Area of Science:

  • Toxicology
  • Biostatistics
  • Risk Assessment

Background:

  • Developmental toxicity studies inform regulatory safe exposure levels for noncarcinogenic substances.
  • Observed dose-response data in these studies often exhibit nonlinear patterns.
  • Traditional models may not adequately capture these complex patterns.

Purpose of the Study:

  • To develop and apply a flexible regression linear B-spline model for analyzing nonlinear developmental toxicity dose-response data.
  • To improve the characterization of dose-response relationships compared to conventional models.

Main Methods:

  • A linear B-spline regression model was developed.
  • The model was applied to developmental toxicity data from two National Toxicology Program CD-1 mice studies.

Related Experiment Videos

  • Data involved exposure to diethylhexyl phthalate and diethylene glycol dimethyl ether, with litter response measured as the proportion of affected fetuses.

    • Main Results:

    • The B-spline model successfully predicted nonlinear dose-response patterns in both studies.
    • The model demonstrated improved fit compared to the standard logistic dose-response model for both datasets.
    • Nonlinear patterns were observed for diethylhexyl phthalate and diethylene glycol dimethyl ether exposures.

    Conclusions:

    • The linear B-spline model provides a more adequate characterization of nonlinear dose-response data in developmental toxicity studies.
    • This approach offers a valuable tool for regulatory agencies in determining safe exposure levels.
    • The findings highlight the importance of using appropriate models for accurate risk assessment.