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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Identification of an oculomotor biomarker of preclinical Huntington disease

C V P Golding1, C Danchaivijitr, T L Hodgson

  • 1Department of Clinical Neuroscience, Faculty of Medicine, Imperial College, London, UK. c.golding@imperial.ac.uk

Neurology
|April 21, 2006
PubMed

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...