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Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
Published on: January 16, 2013
Increased oxidative stress and oxidative damage associated with chronic bacterial prostatitis
Jun-Fu Zhou1, Wei-Qiang Xiao, Yi-Chun Zheng
1Laboratory for Free Radical Medicine, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China. jfzhou@zju.edu.cn
Asian Journal of Andrology
|April 21, 2006
Summary
Chronic bacterial prostatitis elevates oxidative stress and damage, indicated by increased nitric oxide and malondialdehyde, and decreased antioxidants. This oxidative stress correlates with disease duration.
Area of Science:
- Urology
- Biochemistry
- Oxidative Stress Research
Background:
- Chronic bacterial prostatitis (CBP) is a persistent condition.
- Oxidative stress plays a role in various inflammatory diseases.
- The specific impact of CBP on oxidative stress markers is not fully elucidated.
Purpose of the Study:
- To investigate oxidative stress and damage in chronic bacterial prostatitis patients (CBPP).
- To explore the underlying mechanisms of oxidative stress in CBPP.
- To determine the relationship between disease duration and oxidative stress markers.
Main Methods:
- A case-control study involving 70 CBPP and 70 healthy adult volunteers (HAV).
- Measurement of plasma nitric oxide (NO), vitamin C (VC), vitamin E (VE), and beta-carotene (beta-CAR).
- Assay of erythrocyte malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) via spectrophotometry.
Main Results:
- CBPP patients exhibited significantly higher plasma NO and erythrocyte MDA levels compared to HAV.
- CBPP patients showed significantly lower plasma VC, VE, beta-CAR, and erythrocyte SOD, CAT, and GPX activities.
- Disease duration in CBPP correlated with increased NO and MDA, and decreased antioxidant markers.
Conclusions:
- Chronic bacterial prostatitis is associated with increased oxidative stress and damage.
- The observed oxidative stress is closely linked to the duration of the disease.
- These findings highlight the role of oxidative mechanisms in the pathophysiology of CBP.
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