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Updated: Aug 9, 2026
04:22
Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles
Published on: May 20, 2024
[New therapeutic options in Alzheimer's disease]
P J García-Ruiz Espiga1, A Echeverría, A García-Torres
1Servicio de Neurología, Fundación Jiménez Díaz, Madrid, Spain. pgarcia@fjd.es
Revista De Neurologia
|April 21, 2006
Summary
Current Alzheimer's disease (AD) treatments target cholinergic deficits. However, exploring other pathways, like the glutamatergic system, offers new therapeutic strategies for AD.
Area of Science:
- Neuroscience
- Pharmacology
Context:
- Alzheimer's disease (AD) is characterized by cholinergic neurotransmission loss.
- Emerging evidence indicates glutamatergic pathway dysfunction in AD pathogenesis.
Purpose:
- To explore therapeutic strategies beyond cholinesterase inhibitors for Alzheimer's disease.
- To investigate the potential of targeting the glutamatergic system in AD treatment.
Summary:
- Current AD therapy primarily uses cholinesterase inhibitors, targeting cholinergic deficits.
- Alternative approaches include targeting the glutamatergic system with agents like milacemide, cicloserine, ampakines, and memantine.
- Lithium and anti-inflammatory agents also represent potential therapeutic avenues for AD.
Impact:
- Highlights the need for multifaceted therapeutic approaches in Alzheimer's disease.
- Suggests novel drug targets and treatment strategies for AD management.
- Broadens the scope of potential interventions for Alzheimer's disease treatment and prevention.
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