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Related Concept Videos

Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

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Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
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Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting.

J M Ezzo1, M A Richardson, A Vickers

  • 1James P. Swyers Enterprises, 1905 West Rogers Ave, Baltimore, Maryland 21209, USA. jeanetteezzo@prodigy.net

The Cochrane Database of Systematic Reviews
|April 21, 2006
PubMed
Summary

Acupuncture-point stimulation, including electroacupuncture and acupressure, shows promise in reducing acute chemotherapy-induced vomiting and nausea. Further research is needed to confirm clinical relevance, especially for refractory symptoms.

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Area of Science:

  • Integrative oncology
  • Complementary and alternative medicine

Background:

  • Chemotherapy-induced nausea and vomiting (CINV) remain significant challenges despite advances in antiemetic pharmacotherapy.
  • Expert panels recommend exploring additional methods to manage CINV symptoms.

Purpose of the Study:

  • To evaluate the efficacy of acupuncture-point stimulation for managing acute and delayed chemotherapy-induced nausea and vomiting (CINV) in cancer patients.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) involving various acupuncture-point stimulation methods (needles, electroacupuncture, acupressure, magnets).
  • Searched multiple databases including MEDLINE, EMBASE, and Cochrane registers.
  • Pooled data using fixed effect models to calculate relative risks, standardized mean differences, and weighted mean differences.

Main Results:

  • Acupuncture-point stimulation, as a whole, significantly reduced the incidence of acute vomiting (RR = 0.82).
  • Electroacupuncture and needle stimulation were effective in reducing acute vomiting.
  • Acupressure demonstrated a significant reduction in acute nausea severity (SMD = -0.19).
  • Noninvasive electrostimulation showed no significant benefit.

Conclusions:

  • Acupuncture-point stimulation exhibits a biologic effect on CINV, complementing existing antiemetic therapies.
  • Electroacupuncture shows potential for acute chemotherapy-induced vomiting, but further trials with state-of-the-art antiemetics and refractory patients are warranted.
  • Self-administered acupressure may offer a protective effect against acute nausea and is easily teachable, though placebo-controlled studies are needed.