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Related Experiment Videos

Low level laser therapy for treating tuberculosis.

V V Vlassov1, H G MacLehose

  • 1Russian Branch of the Nordic Cochrane Centre, PO Box 13, Moscow, Russia, 109451. vlassov@cochrane.ru

The Cochrane Database of Systematic Reviews
|April 21, 2006
PubMed
Summary
This summary is machine-generated.

Low level laser therapy (LLLT) as an adjunct to antituberculous drugs for tuberculosis treatment lacks reliable evidence. Further high-quality randomized controlled trials are needed to assess LLLT efficacy and safety in tuberculosis patients.

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Area of Science:

  • Medical research
  • Infectious diseases
  • Complementary medicine

Background:

  • Tuberculosis (TB) treatment primarily relies on antituberculous drugs.
  • Low level laser therapy (LLLT) is sometimes used alongside TB drugs, particularly in the former Soviet Union and India.

Purpose of the Study:

  • To evaluate the effectiveness of LLLT combined with antituberculous drugs compared to antituberculous drugs alone for treating tuberculosis.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (MEDLINE, EMBASE, CENTRAL, etc.) up to December 2005.
  • Included randomized controlled trials (RCTs) comparing LLLT plus antituberculous drugs with antituberculous drugs alone in TB patients.
  • Two independent reviewers assessed trial quality and extracted data.

Main Results:

  • Only one poorly reported RCT involving 130 participants met the inclusion criteria.
  • The trial lacked crucial details on randomization, allocation concealment, and participant group allocation, preventing data analysis.
  • No reliable data on outcomes like sputum conversion time could be extracted.

Conclusions:

  • Current evidence does not support the use of LLLT for treating tuberculosis.
  • There is a critical need for well-designed RCTs to establish the efficacy and safety of LLLT in TB management.