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Related Experiment Videos

Thrombolytic therapy for pulmonary embolism.

B Dong1, Y Jirong, G Liu

  • 1West China Hospital, Sichuan University, Clinical Epidemiology, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041. birongdong@hotmail.com

The Cochrane Database of Systematic Reviews
|April 21, 2006
PubMed
Summary

Thrombolytic therapy shows similar effectiveness to heparin for pulmonary embolism but carries a higher risk of bleeding. More research is needed to determine its benefits, especially in different patient groups.

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Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Pharmacology

Background:

  • Thrombolytic therapy is typically reserved for severe pulmonary embolism (PE).
  • While potentially faster at dissolving clots than heparin, concerns exist regarding bleeding risks.

Purpose of the Study:

  • To evaluate the efficacy and safety of thrombolytic therapy for acute pulmonary embolism (PE).

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) comparing thrombolytics with placebo or heparin.
  • Searches included major databases and hand-searched journals up to February 2006.

Main Results:

  • Thrombolytics showed similar rates of death and PE recurrence compared to heparin alone.
  • A higher incidence of major and minor bleeding events was observed with thrombolytics.

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  • Thrombolytics improved hemodynamic and imaging outcomes compared to heparin alone.

    • Conclusions:

    • Limited evidence prevents definitive conclusions on thrombolytic therapy's superiority over heparin for PE.
    • Further high-quality, double-blind RCTs are necessary, particularly with subgroup analyses for hemodynamic stability.