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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Proteomic technology for biomarker profiling in cancer: an update
Moulay A Alaoui-Jamali1, Ying-jie Xu
1Lady Davis Institute for Medical Research and Segal Comprehensive Cancer Center, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Que. H3T 1E2, Canada. moulay.alaoui-jamali@mcgill.ca
Journal of Zhejiang University. Science. B
|April 21, 2006
Summary
Discovering novel cancer biomarkers is crucial for early detection due to cancer
Area of Science:
- Proteomics and Cancer Biology
Background:
- Cancer progression and early detection are hindered by the complexity and heterogeneity of the disease.
- Advanced cancers lack effective treatments, underscoring the need for improved diagnostic tools.
Purpose of the Study:
- To review current research on high-resolution proteomic technologies for cancer biomarker discovery and monitoring.
- To highlight the potential of proteomic analysis in identifying novel biomarkers for early cancer detection.
Main Methods:
- Review of high-resolution proteomic technologies.
- Analysis of proteome complexity, including posttranslational modifications.
- Focus on extracellular proteins as potential serum biomarkers.
Main Results:
- The cancer proteome is highly complex, with over 1.5 million potential proteins due to modifications.
- Ultra-high resolution proteomic technology is essential for accurate protein quantification and data acquisition.
- Secreted and cleaved proteins in the extracellular milieu show promise as diagnostic biomarkers.
Conclusions:
- Advancements in high-resolution proteomic technology are vital for overcoming challenges in cancer biomarker discovery.
- Proteomic approaches offer significant potential for improving early cancer detection and patient outcomes.
