Related Experiment Videos
Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects
A Ceriello1, D Giugliano, A Quatraro
1Cattedra di Diabetologia e Dietoterapia I Facoltà di Medicina, Università di Napoli, Italia.
Insights
Antioxidants like vitamin C, thiopronine, and glutathione show potential anti-hypertensive effects in diabetic and hypertensive individuals. Higher doses of thiopronine and glutathione significantly lowered blood pressure in some subjects.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiovascular Medicine
Background:
- Hypertension is a significant global health concern.
- Oxidative stress and nitric oxide imbalance are implicated in hypertension development.
- Antioxidants are being investigated for their potential cardiovascular benefits.
Purpose of the Study:
- To investigate the acute anti-hypertensive effects of vitamin C, thiopronine, and glutathione.
- To assess these effects in hypertensive subjects and diabetic patients (both hypertensive and non-hypertensive).
Main Methods:
- Administration of three antioxidant agents: vitamin C, thiopronine, and glutathione.
- Dosage variations (6 mmol and 12 mmol) were tested.
- Blood pressure measurements were taken in healthy, hypertensive, and diabetic subjects.
Main Results:
- Antioxidants had no significant effect on blood pressure in healthy individuals at a 6 mmol dose.
- Thiopronine and glutathione demonstrated a significant hypotensive effect at a 12 mmol dose.
- The study observed varying responses in hypertensive and diabetic patient groups.
Conclusions:
- Antioxidants may possess vasodilatory properties.
- An imbalance in the nitric oxide-free radical interaction could contribute to hypertension.
- Further research into antioxidants for hypertension management is warranted.
Abstract:
1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported. 2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect at a dose of 12 mmol. 3. These data suggest that anti-oxidants might have a dilatatory effect and that an imbalance of the nitric oxide-free radical interaction might facilitate the development of hypertension in humans.