Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peroxyl radical clocks.

Bill Roschek1, Keri A Tallman, Christopher L Rector

  • 1Department of Chemistry and Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA.

The Journal of Organic Chemistry
|April 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suppression of Lipid Peroxidation by Necrostatins and Their Potential for Dual Targeting of Ferroptosis and Necroptosis.

Journal of medicinal chemistry·2026
Same author

Transcriptomic and functional responses of human airway cells to vaped ∆8-THC and its oxidation product ∆8-THCQ.

Scientific reports·2026
Same author

Chemical Mechanisms of Lipid Peroxidation.

Redox biochemistry and chemistry·2026
Same author

Macrocyclic oxygen transfer in the conversion of fatty acid hydroperoxide to a single species of triol in physiological saline.

Organic & biomolecular chemistry·2026
Same author

Implementation of the FENIX assay to assess the anti-ferroptotic properties of test compounds.

Methods in cell biology·2026
Same author

Dual valorization of sewage sludge ash through phosphorus recovery and wastewater remediation.

Journal of environmental management·2026

New peroxyl radical clocks, based on methyl linoleate or allylbenzene, accurately measure reaction rates. This method quantizes inhibition and propagation rate constants for antioxidant research.

Area of Science:

  • Chemistry
  • Biochemistry
  • Physical Chemistry

Background:

  • Peroxyl radicals are key intermediates in oxidation processes.
  • Accurate measurement of peroxyl radical reactions is crucial for understanding oxidative stress and antioxidant efficacy.
  • Existing methods for determining rate constants can be limited in scope or accuracy.

Purpose of the Study:

  • To develop and calibrate novel peroxyl radical clocks.
  • To establish a reliable methodology for quantifying peroxyl radical reaction kinetics.
  • To determine inhibition and propagation rate constants in various systems.

Main Methods:

  • Developed peroxyl radical clocks utilizing methyl linoleate or allylbenzene.
  • Calibrated clocks via competition with known hydrogen atom donors like alpha-tocopherol and methyl linoleate.

Related Experiment Videos

  • Employed unimolecular beta-fragmentation (k(beta)) versus bimolecular reaction (k(H)) competition principles.

    • Main Results:

    • Successfully calibrated peroxyl radical clocks with established rate constants.
    • Demonstrated the application of the clock methodology across a wide range of rate constants (10^0 to 10^7 M^-1 s^-1).
    • Provided accurate measurements for inhibition and propagation rate constants.

    Conclusions:

    • The developed peroxyl radical clocks offer a robust tool for kinetic studies.
    • This methodology enhances the ability to assess antioxidant activity and oxidative processes.
    • The calibrated clocks are valuable for research in lipid peroxidation and related fields.