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Updated: Aug 9, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Efficacy of alemtuzumab in organ transplantation: current clinical status

Gaetano Ciancio1, George W Burke, Maria E Warque

  • 1Department of Surgery, Division of Transplantation, University of Miami Miller School of Medicine, Miami, Florida 33101, USA. gciancio@med.miami.edu

Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
|April 22, 2006
PubMed

An overview of the past 5 years of clinical renal transplantation would include progress in (i) the development of protocols with new induction agents (non-depleting versus depleting monoclonal and polyclonal antibodies) designed to reduce the incidence and severity of acute rejection, (ii) the attempt to reduce calcineurin inhibitor short- and long-term nephrotoxicity, and (iii) the attempt to reduce immunosuppression overall if an immunoregulatory state ('tolerance') against donor alloantigens could be achieved. One such induction agent is the humanized anti-CD52 monoclonal antibody alemtuzumab (Campath-1H), which depletes T cells (most potently), as well as B cells and other lymphoid subsets, and may decrease the dosage or need for concurrent maintenance immunosuppressive agents.

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