Related Experiment Video

Updated: Aug 9, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

The p53 response during DNA damage: impact of transcriptional cofactors

Amanda S Coutts1, Nicholas La Thangue

  • 1Laboratory of Cancer Biology, Division of Medical Sciences, University of Oxford, Oxford OX3 9DU, UK.

Biochemical Society Symposium
|April 22, 2006
PubMed

Insights

Defects in DNA damage response pathways can cause tumors. This study explores how novel cofactors, JMY and Strap, regulate the tumor suppressor p53, crucial for preventing cancer by controlling cell cycle and apoptosis.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Tumor suppressor p53 is vital for DNA damage response and preventing tumorigenesis.
  • p53 activity is tightly regulated at multiple levels, influenced by various cofactors.
  • Damage sensors like ATM and ATR activate p53 following DNA damage.

Purpose of the Study:

  • To investigate the role of novel p53 cofactors, JMY and Strap, in regulating p53 activity.
  • To understand how these cofactors impact the DNA damage response pathway.

Main Methods:

  • Literature review and discussion of existing research on p53 cofactors.
  • Focus on the functional mechanisms of JMY (junction-mediating and regulatory protein) and Strap (serine/threonine-kinase-receptor-associated protein).

Main Results:

  • Identified JMY and Strap as key cofactors influencing p53 activity.
  • Highlighted their involvement in the transcriptional regulation of genes controlling cell cycle and apoptosis.
  • Emphasized the importance of cofactor-mediated regulation for tumor suppression.

Conclusions:

  • Precise regulation of p53 by cofactors like JMY and Strap is critical for suppressing tumor development.
  • Further research into these novel cofactors can reveal new therapeutic targets for cancer.

More Related Videos

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

Related Concept Videos

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...